Pair Name	Berberine, Erlotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Phosphorylation	EGFR	hsa1956
	Down-regulation	Phosphorylation	MAPK1	hsa5594
In Vitro Model	A-431	Skin squamous cell carcinoma	Homo sapiens (Human)	CVCL_0037
	NCI-H1666	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1485
	NCI-H441	Lung papillary adenocarcinoma	Homo sapiens (Human)	CVCL_1561
	NCI-H1781	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1494
In Vivo Model	A431 cells (5×10⁶) were suspended in 200 µL of normal saline and subcutaneously implanted into 6-7-week-old male athymic nude mice.
Result	Our data supported use of BBR in combination with erlotinib as a novel strategy for treatment of patients with EGFR positive tumors.